Description

(4R,5R)-4,5-Dihydro-5-[4-(Methylsulfonyl)Phenyl]-2-Phenyl-4-Oxazolemethanol-D3 is a high-purity, deuterium-labeled oxazoline derivative, serving as a critical stable isotope-labeled intermediate. Its primary value lies in enabling advanced research and development, particularly in the fields of pharmaceutical discovery and analytical chemistry, by providing a non-radioactive isotopic tracer. This compound is essential for scientists and manufacturers in the pharmaceutical, agrochemical, and contract research organization (CRO) sectors who require precise metabolic and pharmacokinetic studies.

Application

• Pharmaceutical Reference Standard: Used as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the quantitative analysis of its non-deuterated counterpart in biological matrices.
• Metabolic Pathway Tracing: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion (ADME) of lead compounds.
• Isotope Dilution Mass Spectrometry (IDMS): A key component in high-accuracy quantification methods, improving precision and reliability in analytical assays.
• Mechanistic Biochemical Research: Facilitates the study of reaction mechanisms and enzymatic processes where hydrogen/deuterium exchange is relevant.
• Process Chemistry Development: Acts as a labeled starting material or intermediate in the synthesis of more complex deuterated active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(4R,5R)-4,5-Dihydro-5-[4-(Methylsulfonyl)Phenyl]-2-Phenyl-4-Oxazolemethanol-D3
CAS No.	1246814-83-4
Molecular Formula	C17H14D3NO4S
Molecular Weight	328.39 g/mol (for deuterated form)
Synonyms	4-Oxazolemethanol, 4,5-dihydro-5-[4-(methylsulfonyl)phenyl]-2-phenyl-, (4R,5R)-, D3; (4R,5R)-5-(4-Methanesulfonylphenyl)-2-phenyl-4,5-dihydrooxazole-4-methanol-d3; Deuterated (4R,5R)-Fenobam metabolite intermediate; [D3]-(4R,5R)-4,5-Dihydro-5-(4-(methylsulfonyl)phenyl)-2-phenyl-4-oxazolemethanol; (R,R)-5-(4-Methylsulfonylphenyl)-2-phenyl-4,5-dihydrooxazole-4-methanol-d3; Stable Isotope Labeled Oxazoline Alcohol.
EINECS	Contact for details

Quality Control

Every batch of (4R,5R)-4,5-Dihydro-5-[4-(Methylsulfonyl)Phenyl]-2-Phenyl-4-Oxazolemethanol-D3 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive characterization using NMR (¹H, ¹³C), Mass Spectrometry, and HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically >97% by HPLC), deuterium incorporation (typically >98 atom % D), and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Deuterium Content (MS)	≥ 98 atom % D
Specific Rotation	Contact for details
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.