Description

Tetrahydrozoline-D4 Hydrochloride is a deuterated isotopologue of the well-known α-adrenergic agonist, tetrahydrozoline hydrochloride, where four hydrogen atoms are replaced by deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative analytical methods, ensuring the highest accuracy and reliability in mass spectrometry-based measurements. It is primarily required by pharmaceutical research and development laboratories, clinical testing facilities, and forensic science institutions for applications in pharmacokinetic studies, drug metabolism research, and bioanalytical method validation.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of tetrahydrozoline and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion (ADME) of the parent drug.
• Forensic Toxicology: Enables accurate measurement of tetrahydrozoline concentrations in forensic analyses for cases of suspected overdose or misuse.
• Clinical Research: Supports bioanalytical method development and validation for clinical trials involving tetrahydrozoline-containing formulations.
• Quality Control in Manufacturing: Serves as a reference standard for the quality assurance of active pharmaceutical ingredients (APIs) and finished drug products.
• Metabolite Identification: Aids in the structural elucidation and quantification of drug metabolites formed in vitro or in vivo.

Basic Information

Product Name	Tetrahydrozoline-D4 Hydrochloride
CAS No.	1246814-66-3
Molecular Formula	C13H12D4ClN3 • HCl
Molecular Weight	290.22 g/mol (approx.)
Synonyms	2-(1,2,3,4-Tetrahydro-1-naphthalenyl)-2-imidazoline-d4 Hydrochloride; Tetrahydrozoline-d4 HCl; Tetrahydrozoline (phenyl-d4) Hydrochloride; 1,2,3,4-Tetrahydro-2-(1H-imidazol-2-ylmethyl)naphthalene-d4 Hydrochloride; Deuterated Tetrahydrozoline HCl; Tetrahydrozoline Internal Standard; Visine-d4 (component reference); Isotopically Labeled Tetrahydrozoline.
EINECS	Contact for details

Quality Control

Our Tetrahydrozoline-D4 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR and mass spectrometry, to confirm isotopic enrichment (typically ≥98 atom % D) and chemical purity. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic purity, and identity confirmation is provided with every shipment to ensure traceability and compliance with your research or quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.