Description

6-(2,4-Difluorophenoxy)-8-Methyl-2-[(1,1,5,5-Tetradeuterio-1,5-Dihydroxypentan-3-Yl)Amino]Pyrido[2,3-D]Pyrimidin-7-One is a deuterated pyridopyrimidinone derivative, a sophisticated chemical building block designed for advanced research and development. This compound matters as a high-purity, isotopically labeled intermediate, offering unique metabolic stability and traceability for pharmacokinetic and mechanistic studies. It is primarily needed by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions engaged in the discovery and development of novel kinase inhibitors and targeted therapies.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of deuterated drug candidates, particularly kinase inhibitors.
• Metabolic Tracer: Used in Absorption, Distribution, Metabolism, and Excretion (ADME) studies and drug metabolism research due to its deuterium labels.
• Biochemical Research: Serves as a reference standard or probe in enzymatic assays and target validation studies.
• Preclinical Development: Employed in the development and optimization of lead compounds with improved pharmacokinetic profiles.
• Isotope Labeling Studies: Facilitates mechanistic studies and analytical method development using mass spectrometry (MS) and nuclear magnetic resonance (NMR).
• Contract Manufacturing: Supplied to CDMOs for the custom synthesis of complex, labeled active pharmaceutical ingredients (APIs).

Basic Information

Product Name	6-(2,4-Difluorophenoxy)-8-Methyl-2-[(1,1,5,5-Tetradeuterio-1,5-Dihydroxypentan-3-Yl)Amino]Pyrido[2,3-D]Pyrimidin-7-One
CAS No.	1246814-57-2
Molecular Formula	C19H15D4F2N5O4
Molecular Weight	431.40 g/mol
Synonyms	Deuterated Pyrido[2,3-d]pyrimidin-7-one derivative; 2-[(1,1,5,5-Tetradeuterio-1,5-dihydroxypentan-3-yl)amino]-6-(2,4-difluorophenoxy)-8-methylpyrido[2,3-d]pyrimidin-7-one; 6-(2,4-Difluorophenoxy)-8-methyl-2-[(1,1,5,5-tetradeuteriopentan-1,5-diol-3-yl)amino]pyrido[2,3-d]pyrimidin-7-one; Deuterated Kinase Inhibitor Intermediate; [D4]-Labeled Pyridopyrimidinone; CAS 1246814-57-2
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with a typical purity of ≥95% (by HPLC), tailored to meet specific research requirements. Each batch is supported by comprehensive analytical data, including HPLC, NMR, and MS. Certificates of Analysis (COA) detailing identity, purity, and isotopic enrichment are available upon request. Our quality system is designed to support GMP-grade development upon scale-up.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. Keep the container in a dry, cool, and well-ventilated place. For long-term storage, consider storing under an inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0%
Isotopic Enrichment (MS)	≥98 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.