Description

2,5-Anhydro-D-Glucitol-1,6-Bis-(Dibenzylphosphate) CAS NO 1246812-10-1 is a specialized, high-purity synthetic intermediate featuring a unique anhydro-glucitol core with protected phosphate groups. This compound is critical for advanced research and development in carbohydrate and nucleotide chemistry, offering a protected scaffold for the synthesis of complex bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on developing novel therapeutics, enzyme inhibitors, and molecular probes.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of nucleotide analogs, prodrugs, and other bioactive molecules targeting metabolic pathways.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving kinases, phosphatases, and carbohydrate-processing enzymes.
• Glycochemistry: Serves as a protected precursor for the development of complex glycoconjugates, glycomimetics, and labeled sugars for diagnostic applications.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore the role of phosphorylated sugar derivatives in drug discovery.
• Process Development: Used in scaling up synthetic routes for novel active pharmaceutical ingredients (APIs) requiring specific phosphorylated carbohydrate motifs.
• Academic Synthesis: A valuable reagent for teaching and demonstrating advanced organic synthesis techniques, including phosphorylation and protecting group strategies.

Basic Information

Product Name	2,5-Anhydro-D-Glucitol-1,6-Bis-(Dibenzylphosphate)
CAS No.	1246812-10-1
Molecular Formula	C32H34O11P2
Molecular Weight	656.55 g/mol
Synonyms	1,6-Bis-O-(dibenzylphosphoryl)-2,5-anhydro-D-glucitol; 2,5-Anhydro-1,6-di-O-(dibenzylphosphono)-D-glucitol; D-Glucitol, 2,5-anhydro-1,6-bis[O-(dibenzylphosphato)]-; 2,5-Anhydro-D-glucitol 1,6-bis(dibenzyl phosphate); Anhydroglucitol bis(dibenzyl phosphate); Dibenzyl 2,5-anhydro-D-glucitol-1,6-diyl bis(phosphate); 1,6-Di-O-(dibenzylphosphoryl)-2,5-anhydro-D-glucitol
EINECS	Contact for details

Quality Control

Every batch of 2,5-Anhydro-D-Glucitol-1,6-Bis-(Dibenzylphosphate) is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support development and cGMP-grade production for pharmaceutical applications, with full traceability and documentation available.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.