Description

1-Chloro-4-Iodo-2-Methoxy-5-Methylbenzene is a high-purity halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs) and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting specific receptor sites.
• Agrochemical Research: Used in the development and optimization of new herbicides, fungicides, and pesticides, leveraging its halogenated structure.
• Material Science: Acts as a monomer or functionalizing agent in the production of specialty polymers and advanced organic electronic materials.
• Ligand Synthesis: Employed in the preparation of complex ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and validation.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) due to the presence of the iodine substituent.

Basic Information

Product Name	1-Chloro-4-Iodo-2-Methoxy-5-Methylbenzene
CAS No.	1246644-31-4
Molecular Formula	C8H8ClIO
Molecular Weight	282.51 g/mol
Synonyms	4-Chloro-1-iodo-2-methoxy-5-methylbenzene; 2-Methoxy-5-methyl-1-chloro-4-iodobenzene; 5-Chloro-2-iodo-4-methoxytoluene; 1-Chloro-4-iodo-2-methoxy-5-methyl-benzene; 2-Chloro-5-iodo-4-methoxytoluene; Benzene, 1-chloro-4-iodo-2-methoxy-5-methyl-
EINECS	Contact for details

Quality Control

Our 1-Chloro-4-Iodo-2-Methoxy-5-Methylbenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.