Description

(6R)-6-Ethyl-1,4-Bis[(1S)-1-(4-Methoxyphenyl)Ethyl]-2,5-Piperazinedione-3,3,6-D3 is a deuterated diketopiperazine derivative, a high-value synthetic intermediate and reference standard. This compound is specifically engineered for advanced research and development, offering enhanced metabolic stability and traceability in pharmacokinetic and mechanistic studies. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing novel therapeutics and conducting sophisticated analytical work.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of complex drug candidates, particularly those targeting neurological and oncological pathways.
• Metabolic Tracer: The deuterium (D3) labeling makes it an essential tool for mass spectrometry-based studies of drug metabolism, absorption, distribution, and excretion (ADME).
• Reference Standard: Used as a certified standard for quality control (QC) and analytical method development and validation in GMP/GLP environments.
• Chemical Biology Probe: Employed in research to investigate enzyme mechanisms and protein-ligand interactions where isotopic labeling is required.
• Process Chemistry: Acts as a key chiral intermediate in the scalable synthesis of enantiomerically pure compounds.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis, medicinal chemistry, and stereochemistry.

Basic Information

Product Name	(6R)-6-Ethyl-1,4-Bis[(1S)-1-(4-Methoxyphenyl)Ethyl]-2,5-Piperazinedione-3,3,6-D3
CAS No.	1246496-66-1
Molecular Formula	C24H27D3N2O4
Molecular Weight	413.53 g/mol
Synonyms	(6R)-6-Ethyl-1,4-bis[(1S)-1-(4-methoxyphenyl)ethyl]piperazine-2,5-dione-3,3,6-d3; (6R)-6-Ethyl-1,4-bis[(1S)-1-(4-methoxyphenyl)ethyl]-2,5-diketopiperazine-3,3,6-d3; Deuterated Diketopiperazine Derivative; (3,3,6-D3)-6-Ethyl-1,4-bis[(1S)-1-(4-methoxyphenyl)ethyl]piperazine-2,5-dione; CAS 1246496-66-1; 1246496-66-1
EINECS	Contact for details

Quality Control

Our (6R)-6-Ethyl-1,4-Bis[(1S)-1-(4-Methoxyphenyl)Ethyl]-2,5-Piperazinedione-3,3,6-D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation and deuterium incorporation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Incorporation (NMR/MS)	≥ 98 atom % D
Specific Rotation	Contact for details
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.