Description

(6S)-6-Ethyl-1,4-Bis[(1S)-1-(4-Methoxyphenyl)Ethyl]-2,5-Piperazinedione-3,3,6-D3 is a deuterated diketopiperazine derivative, a sophisticated chiral building block of significant interest in advanced pharmaceutical research and development. Its core value lies in its precise stereochemistry and the incorporation of deuterium atoms, which can be leveraged to modify the metabolic profile and pharmacokinetics of drug candidates. This high-purity intermediate is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries working on novel therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral scaffold for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disorder research.
• Deuterated Drug Development: Used as a precursor for creating deuterium-labeled drug candidates, a strategy employed to potentially enhance metabolic stability, reduce toxicity, and extend patent life.
• Asymmetric Synthesis: Acts as a versatile building block in stereoselective synthesis, enabling the construction of complex molecules with defined three-dimensional structures.
• Metabolic Studies: Employed in the preparation of internal standards for Liquid Chromatography-Mass Spectrometry (LC-MS) bioanalytical methods, ensuring accurate quantification of drugs and metabolites in biological matrices.
• Medicinal Chemistry Research: Provides a constrained peptidomimetic core for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Process Chemistry: Used in the development and scale-up of optimized synthetic routes for target molecules requiring this specific chiral framework.

Basic Information

Item	Details
Product Name	(6S)-6-Ethyl-1,4-Bis[(1S)-1-(4-Methoxyphenyl)Ethyl]-2,5-Piperazinedione-3,3,6-D3
CAS No.	1246496-59-2
Molecular Formula	C24H27D3N2O4
Molecular Weight	413.53 g/mol (approx.)
Synonyms	(3S,6S)-3,6-Bis[(1S)-1-(4-methoxyphenyl)ethyl]-6-ethyl-3,3,6-trideuteropiperazine-2,5-dione; (6S)-6-Ethyl-1,4-bis[(1S)-1-(4-methoxyphenyl)ethyl]-2,5-diketopiperazine-3,3,6-D3; Deuterated Diketopiperazine Derivative; (3S,6S)-3,6-Bis(α-methyl-4-methoxybenzyl)-6-ethyl-3,3,6-trideutero-2,5-piperazinedione; Chiral Deuterated Piperazinedione; CAS 1246496-59-2
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical development. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and isotopic enrichment. Certificates of Analysis (COA) detailing specifications such as chiral purity, chemical purity (by HPLC), deuterium incorporation, and residual solvent levels are available upon request. We adhere to cGMP principles where applicable to support our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under an inert atmosphere at -20°C to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Deuterium Incorporation (MS/NMR)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.