Description

1,4-Bis[(1S)-1-(4-Methoxyphenyl)Ethyl]-2,5-Piperazinedione-D4 is a deuterated isotopologue of a chiral diketopiperazine derivative, specifically designed for advanced research and development applications. This high-purity compound is critical for studies requiring isotopic labeling, such as internal standards for mass spectrometry and investigations into metabolic pathways and pharmacokinetics. It is primarily utilized by pharmaceutical R&D laboratories, analytical chemistry service providers, and academic institutions focused on medicinal chemistry and drug discovery.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a stable, non-interfering reference compound for the precise quantification of its non-deuterated counterpart in complex biological matrices.
• Metabolic and Pharmacokinetic (PK/PD) Studies: Used as a tracer to study the absorption, distribution, metabolism, and excretion (ADME) profiles of pharmaceutical candidates.
• Deuterium Labeling in Medicinal Chemistry: Employed in the synthesis of deuterated drug molecules to potentially alter metabolic stability and improve therapeutic profiles.
• Biochemical Research: Acts as a specialized reagent or probe in studies involving enzyme mechanisms or protein-ligand interactions where isotopic labeling is required.
• Analytical Method Development: Essential for developing and validating highly sensitive and specific analytical methods in compliance with regulatory guidelines.

Basic Information

Product Name	1,4-Bis[(1S)-1-(4-Methoxyphenyl)Ethyl]-2,5-Piperazinedione-D4
CAS No.	1246496-54-7
Molecular Formula	C22H20D4N2O4
Molecular Weight	376.48 g/mol (approx.)
Synonyms	1,4-Bis[(1S)-1-(4-Methoxyphenyl)ethyl]-2,5-diketopiperazine-d4; (3S,6S)-3,6-Bis[1-(4-methoxyphenyl)ethyl]piperazine-2,5-dione-d4; Deuterated Diketopiperazine Derivative; Chiral Diketopiperazine-d4; (S,S)-Bis(4-methoxyphenethyl)diketopiperazine-d4; DKP-d4 Derivative; 1246496-54-7 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Every batch of 1,4-Bis[(1S)-1-(4-Methoxyphenyl)Ethyl]-2,5-Piperazinedione-D4 is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including NMR, HPLC, and MS, to ensure high chemical purity, isotopic enrichment, and chiral integrity. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.