Description

1-Hexacosanoyl-D4-2-Hydroxy-Sn-Glycero-3-Phosphocholine is a high-purity, deuterated phospholipid derivative, specifically designed for advanced research and analytical applications. This compound is critical for studies requiring precise isotopic labeling to investigate lipid metabolism, membrane dynamics, and signaling pathways. It is an essential reagent for pharmaceutical R&D, academic research, and specialized diagnostic development in the life sciences sector.

Application

• Biomarker Research & Lipidomics: Used as an internal standard for the accurate quantification of phosphatidylcholines in mass spectrometry-based lipidomic profiling.
• Drug Metabolism & Pharmacokinetics (DMPK): Serves as a stable isotope-labeled tracer to study the absorption, distribution, metabolism, and excretion (ADME) of lipid-based drug candidates.
• Membrane Biophysics: Employed in nuclear magnetic resonance (NMR) and other spectroscopic techniques to probe the structure and fluidity of model lipid bilayers.
• Diagnostic Assay Development: Acts as a critical component in calibrating assays for clinical diagnostics related to lipid disorders and metabolic diseases.
• Pharmaceutical R&D: Utilized in formulation studies for liposomal drug delivery systems and in-target engagement studies for lipid-modifying therapeutics.

Basic Information

Product Name	1-Hexacosanoyl-D4-2-Hydroxy-Sn-Glycero-3-Phosphocholine
CAS No.	1246303-15-0
Molecular Formula	C34H65D4NO8P
Molecular Weight	~662.9 g/mol
Synonyms	LysoPC(26:0-d4); LPC(26:0-d4); 1-Hexacosanoyl-2-hydroxy-sn-glycero-3-phosphocholine-d4; Deuterated Lyso-Phosphatidylcholine (26:0); 1-(26:0)-Lyso-2-phosphatidylcholine-d4; [D4]-LPC(26:0); (2R)-2-Hydroxy-3-(trimethylazaniumyl)propyl (26,26,26,26-D4)hexacosanoate phosphate
EINECS	Contact for details

Quality Control

Our 1-Hexacosanoyl-D4-2-Hydroxy-Sn-Glycero-3-Phosphocholine is manufactured under strict quality systems suitable for research and analytical use. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and MS, to ensure high chemical and isotopic purity. Certificates of Analysis (COA) detailing batch-specific results are provided to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. For long-term storage, desiccate to protect against moisture. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Enrichment (MS)	≥ 98 atom % D
Chemical Purity (Titration/Assay)	≥ 97%
Solubility	Soluble in chloroform, methanol, ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.