Description

25,26,26,26,27,27-Hexadeuterocholest-5-Ene-3,27-Diol is a high-purity, deuterated sterol derivative, specifically designed for advanced research and development applications. This compound is valued for its isotopic labeling, which provides a stable, non-radioactive tracer for metabolic and pharmacokinetic studies. It is primarily utilized by pharmaceutical researchers, analytical laboratories, and academic institutions engaged in lipid metabolism, drug discovery, and biomarker analysis.

Application

• Internal Standard for Mass Spectrometry: Serves as a critical quantitative reference in LC-MS/MS and GC-MS analysis of sterols and related metabolites.
• Metabolic Pathway Tracing: Used as a deuterium-labeled tracer to study cholesterol biosynthesis, transport, and catabolism in biological systems.
• Pharmaceutical R&D: Employed in the development and validation of assays for novel therapeutic agents targeting lipid pathways.
• Biomarker Research: Facilitates the accurate measurement of endogenous sterol levels in clinical and preclinical samples.
• Stable Isotope Labeling: Provides a tool for mechanistic studies in enzymology and molecular biology without radioactive hazards.

Basic Information

Product Name	25,26,26,26,27,27-Hexadeuterocholest-5-Ene-3,27-Diol
CAS No.	1246302-95-3
Molecular Formula	C₂₇H₄₂D₆O₂
Molecular Weight	~ 418.7 g/mol
Synonyms	25,26,26,26,27,27-Hexadeutero-5-cholestene-3β,27-diol; Deuterated Cholestenediol; [26,26,26,27,27,27-²H₆]-Cholest-5-ene-3β,27-diol; 3β,27-Dihydroxy-25,26,26,26,27,27-hexadeuterocholest-5-ene; Hexadeuterocholestenediol; Deuterium Labeled Sterol Diol; Stable Isotope Labeled Cholesterol Metabolite
EINECS	Contact for details

Quality Control

Our 25,26,26,26,27,27-Hexadeuterocholest-5-Ene-3,27-Diol is manufactured under strict quality systems to ensure high chemical and isotopic purity suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity, isotopic enrichment, and impurity profile. We adhere to cGMP principles for research chemicals, ensuring reliable batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is light-sensitive (store away from light). For long-term storage, consider storing under inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.