Description

Cholest-5-Ene-3,22(R)-Diol-D7 is a high-purity, deuterium-labeled sterol derivative, specifically designed for use as an analytical standard and a key intermediate in advanced research. This compound is essential for ensuring accuracy and traceability in quantitative mass spectrometry and metabolic pathway studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on lipidomics, biomarker discovery, and drug metabolism and pharmacokinetics (DMPK) research.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the precise quantification of cholesterol and its metabolites in biological matrices.
• Metabolic Pathway Tracing: Enables detailed investigation of sterol biosynthesis and metabolic flux analysis in research settings.
• Biomarker Research: Serves as a critical reference compound in the development of assays for oxysterols and other sterol-based biomarkers.
• Pharmaceutical Intermediate: Acts as a labeled building block in the synthesis of novel deuterated drug candidates for enhanced metabolic stability.
• Quality Control Reference: Provides a certified reference material for calibrating analytical instruments and validating methods in quality control laboratories.

Basic Information

Product Name	Cholest-5-Ene-3,22(R)-Diol-D7
CAS No.	1246302-93-1
Molecular Formula	C₂₇H₄₁D₇O₂
Molecular Weight	~411.7 g/mol
Synonyms	(22R)-22-Hydroxycholesterol-d7; 22(R)-Hydroxycholesterol-d7; Cholest-5-ene-3β,22(R)-diol-d7; 3β,22(R)-Dihydroxycholest-5-ene-d7; Deuterated 22(R)-HC; 22R-HC-d7; Deuterium Labeled 22(R)-Hydroxycholesterol
EINECS	Contact for details

Quality Control

Our Cholest-5-Ene-3,22(R)-Diol-D7 is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical identity. Each batch is characterized by NMR, HPLC, and mass spectrometry to confirm deuterium incorporation and chemical purity. A comprehensive Certificate of Analysis (COA) detailing isotopic purity, chemical purity, and analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.