Description

1-Desoxymethylsphinganine-D5 (M17:0) is a deuterium-labeled analog of a key sphingolipid metabolite, specifically designed for use as an internal standard in quantitative mass spectrometry. This high-purity, isotopically labeled compound is essential for achieving accurate and reliable quantification in complex biological matrices, correcting for variations in sample preparation and instrument response. It is primarily utilized by researchers and analytical laboratories in the fields of lipidomics, metabolomics, and pharmaceutical development for biomarker discovery and drug metabolism studies.

Application

• Quantitative Lipidomics & Metabolomics: Serves as a critical internal standard for the precise LC-MS/MS quantification of endogenous sphinganine and related sphingolipid species in tissue, plasma, and cell culture samples.
• Biomarker Research: Enables accurate measurement of sphingolipid pathway metabolites for studying their roles in disease mechanisms, including cancer, neurodegenerative disorders, and metabolic syndromes.
• Drug Discovery & Pharmacokinetics (PK): Used in ADME (Absorption, Distribution, Metabolism, Excretion) studies to track drug-induced alterations in sphingolipid metabolism and for developing bioanalytical assays.
• Clinical Diagnostics Development: Supports the development and validation of robust clinical assays aimed at measuring sphingolipids as potential diagnostic or prognostic indicators.
• Nutritional & Biochemical Research: Facilitates studies on how diet, supplements, or environmental factors influence the sphingolipidome.
• Quality Control for Reference Materials: Acts as a calibrant or reference compound for ensuring the accuracy and consistency of commercial and in-house analytical standards.

Basic Information

Product Name	1-Desoxymethylsphinganine-D5 (M17:0)
CAS No.	1246298-43-0
Molecular Formula	C17H30D5NO2
Molecular Weight	~287.5 g/mol
Synonyms	D5-Sphinganine; Deuterated Sphinganine (d5); (2S,3R)-2-Amino-1,3-heptadecanediol-1,1,2,3,3-d5; M17:0-d5 Internal Standard; 1-Desoxymethyl-D5-sphinganine; Sphinganine-d5; Lipidomix® M17:0-d5 (potential trade name); D-erythro-Sphinganine-1,1,2,3,3-d5
EINECS	Contact for details

Quality Control

Every batch of 1-Desoxymethylsphinganine-D5 (M17:0) is manufactured and analyzed under strict quality protocols to ensure the high isotopic purity and chemical integrity required for sensitive mass spectrometry applications. Our quality assurance includes rigorous testing for isotopic enrichment (≥98 atom % D), chemical purity (by HPLC), and structural confirmation. A comprehensive Certificate of Analysis (COA) detailing lot-specific results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation. The product is stable under these conditions for at least 24 months from the date of receipt.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity	≥ 98 atom % D
Water Content (KF)	≤ 1.0 %
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.