Description

(4,4-Dimethyl-D6)Cholest-8(9),24-Dien-3-Ol CAS NO 1246298-30-5 is a high-purity, deuterated sterol derivative, specifically designed for advanced research and analytical applications. This compound serves as a critical internal standard and stable isotope-labeled tracer in mass spectrometry-based lipidomics and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and analytical service providers focused on cholesterol biosynthesis, lipid metabolism, and biomarker discovery.

Application

• Internal Standard for LC-MS/MS: Quantitative analysis of cholesterol and related sterols in biological matrices (plasma, tissues, cells).
• Metabolic Tracer Studies: Investigating cholesterol biosynthesis pathways, flux analysis, and metabolic disorders.
• Lipidomics Research: High-resolution profiling and identification of sterol metabolites in complex samples.
• Pharmaceutical Development: Supporting drug discovery programs targeting lipid metabolism enzymes (e.g., DHCR7, SC4MOL).
• Biomarker Discovery & Validation: Enabling precise measurement of sterol biomarkers for diagnostic applications.
• Reference Material: Calibration and method development in clinical and forensic toxicology laboratories.

Basic Information

Product Name	(4,4-Dimethyl-D6)Cholest-8(9),24-Dien-3-Ol
CAS No.	1246298-30-5
Molecular Formula	C₂₉H₄₂D₆O
Molecular Weight	~ 414.7 g/mol
Synonyms	4,4-Dimethyl-d6-cholesta-8(9),24-dien-3β-ol; Deuterated 4,4-Dimethylcholesta-8(9),24-dien-3-ol; (3β)-4,4-Dimethylcholesta-8(9),24-dien-3-ol-d6; 4,4-Dimethyl-D6-zymosterol; D6-4,4-Dimethylzymosterol; Stable Isotope Labeled Sterol; [D6]-4,4-Dimethylcholest-8(9),24-dien-3-ol
EINECS	Contact for details

Quality Control

Our (4,4-Dimethyl-D6)Cholest-8(9),24-Dien-3-Ol is manufactured under strict quality systems to ensure batch-to-batch consistency and data integrity for sensitive analytical applications. Each lot is characterized by NMR (¹H, ¹³C) and High-Resolution Mass Spectrometry (HRMS) for structural confirmation and isotopic purity assessment. Certificates of Analysis (COA) are provided, detailing purity (by HPLC), chemical purity, and isotopic enrichment (typically >98 atom % D). We support compliance with GMP/GLP guidelines for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to ensure long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (HRMS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (Atom % D)	≥ 98%
Chemical Purity	≥ 90%
Solubility	Soluble in chloroform, DMSO, ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.