Description

5-Ethylthiophene-3-Sulfonyl Chloride is a high-purity, reactive organosulfur building block essential for advanced chemical synthesis. Its core value lies in its sulfonyl chloride functional group, which enables efficient introduction of the sulfonamide moiety, a key pharmacophore in modern drug discovery. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of sulfonamide-based drug candidates, including kinase inhibitors, antibacterial agents, and anti-inflammatory compounds.
• Agrochemical Research: Used to develop novel herbicides, fungicides, and pesticides by incorporating the thiophene-sulfonamide scaffold.
• Material Science: Serves as a monomer or cross-linking agent for creating specialty polymers with specific electronic or surface properties.
• Chemical Biology & Proteomics: Employed as a reactive handle for bioconjugation and the development of activity-based probes targeting specific enzymes.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses serving the life sciences sector.
• Academic Research: Utilized in methodological studies and the exploration of new heterocyclic chemistry and sulfonylation reactions.

Basic Information

Product Name	5-Ethylthiophene-3-Sulfonyl Chloride
CAS No.	1245823-95-3
Molecular Formula	C6H7ClO2S2
Molecular Weight	210.70 g/mol
Synonyms	3-Ethylthiophene-5-sulfonyl chloride; 5-Ethyl-3-thiophenesulfonyl chloride; 3-Thiophenesulfonyl chloride, 5-ethyl-; 5-Ethylthiophene-3-sulphonyl chloride; 1245823-95-3; 5-Ethyl-3-thienylsulfonyl chloride; 3-(Chlorosulfonyl)-5-ethylthiophene
EINECS	Contact for details

Quality Control

Every batch of 5-Ethylthiophene-3-Sulfonyl Chloride is produced and tested under strict quality management protocols to ensure consistency and reliability for sensitive synthetic applications. Our products undergo rigorous quality testing, including HPLC, NMR, and IR spectroscopy, to ensure compliance with industry standards and customer-specific requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent derivative, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.