Description

1-(2,2-Difluoro-Ethyl)-4-Methyl-5-Nitro-1H-Pyrazole is a specialized fluorinated pyrazole derivative, a high-value building block in advanced organic synthesis. Its molecular structure, featuring a difluoroethyl group and a nitro substituent, makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other enzyme modulators.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms can improve lipophilicity and target binding.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of specialized polymers and advanced materials with unique electronic or surface properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific synthesis projects requiring fluorinated heterocycles.

Basic Information

Product Name	1-(2,2-Difluoro-Ethyl)-4-Methyl-5-Nitro-1H-Pyrazole
CAS No.	1245808-12-1
Molecular Formula	C6H7F2N3O2
Molecular Weight	191.14 g/mol
Synonyms	4-Methyl-5-nitro-1-(2,2-difluoroethyl)-1H-pyrazole; 1-(2,2-Difluoroethyl)-4-methyl-5-nitro-1H-pyrazole; 1H-Pyrazole, 1-(2,2-difluoroethyl)-4-methyl-5-nitro-; 1245808-12-1; 5-Nitro-4-methyl-1-(2,2-difluoroethyl)pyrazole; Difluoroethyl nitro methyl pyrazole
EINECS	Contact for details

Quality Control

Every batch of 1-(2,2-Difluoro-Ethyl)-4-Methyl-5-Nitro-1H-Pyrazole is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment, supporting cGMP (current Good Manufacturing Practice) standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.