Description

2-(tert-Butyldimethylsilyl)-4-Methylthiazole is a high-value organosilicon-protected thiazole derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its primary value lies in providing a robust, sterically hindered protecting group for sensitive functionalities, enabling complex multi-step synthesis with high selectivity and yield. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, particularly those containing thiazole or heterocyclic cores.
• Agrochemical Synthesis: Used in the development of novel pesticides, herbicides, and fungicides where the protected thiazole moiety is incorporated into the final active molecule.
• Organometallic Chemistry: Acts as a ligand precursor or a protected substrate in catalytic reactions and metal-complex synthesis.
• Material Science Research: Employed in the development of organic semiconductors, conductive polymers, and advanced functional materials.
• Academic & R&D Laboratories: A versatile reagent for methodological development in synthetic organic chemistry, especially in total synthesis projects.
• Fine Chemical Production: Intermediate for manufacturing specialty chemicals, flavors, fragrances, and dyes requiring specific thiazole derivatives.

Basic Information

Product Name	2-(tert-Butyldimethylsilyl)-4-Methylthiazole
CAS No.	1245782-58-4
Molecular Formula	C10H19NSSi
Molecular Weight	213.42 g/mol
Synonyms	4-Methyl-2-[(1,1-dimethylethyl)dimethylsilyl]thiazole; 4-Methyl-2-(tert-butyldimethylsilyl)thiazole; TBDMS-4-Methylthiazole; 2-(Tert-Butyldimethylsilyl)-4-methylthiazole; 2-(tert-Butyldimethylsilanyl)-4-methyl-thiazole; 2-[(1,1-Dimethylethyl)dimethylsilyl]-4-methylthiazole; 4-Methyl-2-((tert-butyldimethylsilyl)thiazole
EINECS	Contact for details

Quality Control

Our 2-(tert-Butyldimethylsilyl)-4-Methylthiazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We adhere to cGMP principles for production, ensuring traceability and reliability for critical R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.