Description

4-(Difluoromethyl)Bicyclo[2.2.1]Heptan-1-Amine is a specialized bicyclic amine derivative featuring a difluoromethyl substituent, offering a unique combination of structural rigidity and fluorine chemistry. This compound is valued for its role as a key chiral building block and intermediate in advanced organic synthesis, particularly where the introduction of fluorine atoms is critical for modulating the biological activity and physicochemical properties of target molecules. It is primarily sought by pharmaceutical, agrochemical, and advanced materials research sectors for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in fluorinated drug candidates targeting CNS disorders, metabolic diseases, and oncology.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and pesticides where the difluoromethyl group enhances lipophilicity, metabolic stability, and binding affinity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis, enabling the production of enantiomerically pure compounds.
• Advanced Material Research: Incorporated into the design of specialty polymers, liquid crystals, and electronic materials to fine-tune thermal stability, solubility, and electronic properties.
• Fluorine Chemistry Research: An important substrate for studying structure-activity relationships (SAR) and for introducing fluorinated motifs into complex molecular architectures.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex fluorinated intermediates.

Basic Information

Product Name	4-(Difluoromethyl)Bicyclo[2.2.1]Heptan-1-Amine
CAS No.	1245647-64-6
Molecular Formula	C8H13F2N
Molecular Weight	161.19 g/mol
Synonyms	4-(Difluoromethyl)-1-norbornanamine; 4-(Difluoromethyl)bicyclo[2.2.1]heptan-1-amine; 1-Norbornanamine, 4-(difluoromethyl)-; 4-(Difluoromethyl)norbornan-1-amine; Bicyclo[2.2.1]heptan-1-amine, 4-(difluoromethyl)-; 4-(Difluoromethyl)-7,7-dimethylbicyclo[2.2.1]heptan-1-amine (structural variant); 1-Amino-4-(difluoromethyl)norbornane
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethyl)Bicyclo[2.2.1]Heptan-1-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and process development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We can support development with custom purity grades, including pharmaceutical intermediate standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee (Typical, specific grade available)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.