Description

3-(tert-Butyl-Dimethyl-Silanyloxymethyl)-Cyclobutanol CAS NO 1245647-19-1 is a high-value, protected cyclobutanol derivative featuring a tert-butyldimethylsilyl (TBDMS) ether group. This compound serves as a critical chiral building block and synthetic intermediate in advanced organic synthesis, offering chemists a versatile handle for constructing complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Research: Building block for developing novel herbicides, fungicides, and insecticides with specific stereochemical requirements.
• Material Science: Precursor for specialty polymers and advanced materials where the rigid cyclobutane ring structure imparts unique physical properties.
• Asymmetric Synthesis: Used in stereoselective reactions to introduce the protected hydroxymethyl-cyclobutane moiety into target molecules.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies and the exploration of new chemical space in drug discovery programs.
• Process Chemistry: Intermediate in scalable route development for commercial manufacturing of fine chemicals.

Basic Information

Product Name	3-(tert-Butyl-Dimethyl-Silanyloxymethyl)-Cyclobutanol
CAS No.	1245647-19-1
Molecular Formula	C11H24O2Si
Molecular Weight	216.40 g/mol
Synonyms	3-((tert-Butyldimethylsilyloxy)methyl)cyclobutanol; 3-(Hydroxymethyl)cyclobutanol TBDMS ether; 3-(TBDMS-oxymethyl)cyclobutanol; Cyclobutane-1,3-dimethanol, 1-(tert-butyldimethylsilyl) ether; 1-(tert-Butyl-dimethyl-silanyloxymethyl)-cyclobutanol; TBDMS-protected 3-hydroxymethylcyclobutanol; 3-(tert-Butyldimethylsiloxymethyl)cyclobutanol
EINECS	Contact for details

Quality Control

Our production of 3-(tert-Butyl-Dimethyl-Silanyloxymethyl)-Cyclobutanol adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profile is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.