Description

5-Ethynyl-1H-Indazol-3-Amine CAS NO 1245645-87-7 is a high-purity, advanced pharmaceutical intermediate featuring a reactive ethynyl group on an indazole scaffold. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of targeted small-molecule therapeutics. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of kinase inhibitors and other biologically active compounds for oncology and inflammatory disease applications.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in oncology research.
• Kinase Inhibitor Development: Serves as a core scaffold for designing potent and selective inhibitors of various protein kinases.
• Bioconjugation & Probe Synthesis: The reactive alkyne group enables click chemistry for labeling, bioconjugation, and creating chemical probes for biological studies.
• Chemical Biology Research: Used in target identification and validation studies within academic and industrial R&D settings.
• Preclinical Candidate Optimization: Employed in structure-activity relationship (SAR) studies to optimize the potency and pharmacokinetic properties of lead molecules.

Basic Information

Product Name	5-Ethynyl-1H-Indazol-3-Amine
CAS No.	1245645-87-7
Molecular Formula	C9H7N3
Molecular Weight	157.17 g/mol
Synonyms	5-Ethynyl-1H-indazol-3-amine; 3-Amino-5-ethynyl-1H-indazole; 5-Ethynyl-3-amino-1H-indazole; 1H-Indazol-3-amine, 5-ethynyl-; 1245645-87-7; 5-Ethynylindazol-3-ylamine
EINECS	Contact for details

Quality Control

Our 5-Ethynyl-1H-Indazol-3-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurities, and analytical results are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.