Description

cis-tert-Butyl6-Acetyl-3-Azabicyclo[3.1.0]Hexane-3-Carboxylate CAS NO 1245645-37-7 is a high-purity, advanced pharmaceutical intermediate featuring a unique, strained azabicyclo[3.1.0]hexane scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for synthesizing novel, bioactive molecules. It is primarily sought after by pharmaceutical companies and contract research organizations (CROs) focused on developing new therapeutic agents, particularly in areas requiring complex, three-dimensional molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, especially those targeting the central nervous system (CNS).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space and improve drug-like properties.
• Protease Inhibitor Development: The bicyclic lactam structure makes it a valuable precursor for designing novel protease and enzyme inhibitors.
• Asymmetric Synthesis: Employed as a building block in stereoselective synthesis to introduce complex, rigid molecular frameworks into target molecules.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying biological pathways and protein functions.
• Process Chemistry & Scale-Up: Serves as a critical intermediate during the route development and pilot-scale manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	cis-tert-Butyl6-Acetyl-3-Azabicyclo[3.1.0]Hexane-3-Carboxylate
CAS No.	1245645-37-7
Molecular Formula	C14H21NO3
Molecular Weight	251.32 g/mol
Synonyms	(1S,5R,6S)-6-Acetyl-3-(tert-butoxycarbonyl)-3-azabicyclo[3.1.0]hexane; tert-Butyl (1S,5R,6S)-6-acetyl-3-azabicyclo[3.1.0]hexane-3-carboxylate; cis-3-Boc-6-acetyl-3-azabicyclo[3.1.0]hexane; Boc-Acetyl Azabicyclohexane; (1S,5R,6S)-3-(tert-Butoxycarbonyl)-6-acetyl-3-azabicyclo[3.1.0]hexane; Azabicyclo[3.1.0]hexane Carboxylate Derivative; Bicyclic Lactam Intermediate; CAS 1245645-37-7
EINECS	Contact for details

Quality Control

Our cis-tert-Butyl6-Acetyl-3-Azabicyclo[3.1.0]Hexane-3-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and stereochemical integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.