Description

4-(Difluoromethyl)Bicyclo[2.2.2]Octan-1-Amine is a specialized bicyclic amine derivative featuring a difluoromethyl substituent, offering unique steric and electronic properties. This compound is valued as a key building block in advanced organic synthesis, particularly for introducing rigid, fluorinated amine motifs into target molecules. It is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a critical synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and metabolic disease targets.
• Agrochemical Synthesis: Used in creating novel pesticides and herbicides where the bicyclic[2.2.2]octane scaffold and fluorine atoms can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Employed in the design of chiral ligands and organocatalysts for asymmetric synthesis, leveraging its rigid, three-dimensional structure.
• Material Science Research: Acts as a monomer or functional additive in the synthesis of advanced polymers with specific thermal or surface properties.
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research exploring the effects of fluorinated groups on molecular conformation and reactivity.
• Peptidomimetics: Used to construct conformationally restricted, non-natural amino acid analogs for probing protein-protein interactions.

Basic Information

Item	Details
Product Name	4-(Difluoromethyl)Bicyclo[2.2.2]Octan-1-Amine
CAS No.	1245643-16-6
Molecular Formula	C9H15F2N
Molecular Weight	175.22 g/mol
Synonyms	4-(Difluoromethyl)bicyclo[2.2.2]octan-1-amine; 4-(Difluoromethyl)-1-aminobicyclo[2.2.2]octane; 1-Amino-4-(difluoromethyl)bicyclo[2.2.2]octane; Bicyclo[2.2.2]octan-1-amine, 4-(difluoromethyl)-; 1245643-16-6; 4-Difluoromethylbicyclo[2.2.2]octan-1-ylamine
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethyl)Bicyclo[2.2.2]Octan-1-Amine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing all specified parameters. Our quality system is designed to meet the stringent requirements of cGMP for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.