Description

6-Cyclopropyl-8-Fluoroisoquinolin-1(2H)-One is a high-purity fluorinated isoquinolinone derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in its unique molecular scaffold, which is essential for constructing novel active pharmaceutical ingredients (APIs) with targeted therapeutic effects. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of new drugs, particularly in the areas of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to optimize lead compounds.
• Organic Synthesis: Serves as a versatile precursor for constructing complex heterocyclic systems due to its reactive isoquinolinone core and fluorine substituent.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for studying fluorinated heterocycle chemistry and developing new synthetic methodologies.

Basic Information

Product Name	6-Cyclopropyl-8-Fluoroisoquinolin-1(2H)-One
CAS No.	1242156-53-1
Molecular Formula	C₁₂H₁₀FNO
Molecular Weight	203.21 g/mol
Synonyms	8-Fluoro-6-cyclopropyl-1,2-dihydroisoquinolin-1-one; 6-Cyclopropyl-8-fluoro-1,2-dihydroisoquinolin-1-one; 8-Fluoro-6-cyclopropylisoquinolin-1(2H)-one; 1(2H)-Isoquinolinone, 6-cyclopropyl-8-fluoro-; 6-Cyclopropyl-8-fluoroisoquinolin-1-ol (tautomer); 6-Cyclopropyl-8-fluoro-2H-isoquinolin-1-one
EINECS	Contact for details

Quality Control

Our 6-Cyclopropyl-8-Fluoroisoquinolin-1(2H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.