Description

4-Phosphono-D-Phenylalanine is a specialized, non-natural amino acid derivative featuring a phosphonic acid functional group. This compound is of significant value in medicinal chemistry and biochemistry as a key building block for the synthesis of phosphonate-based peptidomimetics and enzyme inhibitors. It is primarily sought by researchers and manufacturers in the pharmaceutical and biotechnology sectors for developing novel therapeutics, particularly targeting enzymes like phosphatases and proteases. The D-configuration of the amino acid center provides unique stereochemical properties essential for creating specific bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of phosphonate-containing drug candidates and active pharmaceutical ingredients (APIs).
• Enzyme Inhibitor Development: Used to create potent and selective inhibitors for enzymes such as tyrosine phosphatases, alkaline phosphatases, and renin.
• Peptidomimetic Research: Serves as a non-hydrolyzable phosphotyrosine mimetic in the design of peptide analogs for signal transduction studies.
• Bioconjugation & Probe Synthesis: Employed in the preparation of affinity labels, activity-based probes, and molecular tools for biochemical assays.
• Material Science & Chelation: Potential use in functionalized surfaces, metal-organic frameworks (MOFs), or as a ligand for metal ion chelation due to its phosphonic acid group.

Basic Information

Product Name	4-Phosphono-D-Phenylalanine
CAS No.	1241680-48-7
Molecular Formula	C9H12NO6P
Molecular Weight	261.17 g/mol
Synonyms	(R)-2-Amino-3-(4-phosphonophenyl)propanoic acid; D-4-Phosphonophenylalanine; Ppa(4-PO3H2)-OH; Fmoc-D-Phe(4-PO(OBzl)OH)-OH (protected form); 4-Phosphono-D-Phe; 4-Phosphonophenylalanine, D- isomer; D-4-Phosphono-Phe
EINECS	Contact for details

Quality Control

Our 4-Phosphono-D-Phenylalanine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity and chiral integrity, NMR and MS for structural confirmation, and KF titration for moisture content. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 2.0%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.