Description

tert-Butyl 3A,4,7,7A-Tetrahydro-1H-Isoindole-2(3H)-Carboxylate is a high-purity, protected amine intermediate of significant importance in advanced organic synthesis. This compound is valued for its role as a versatile building block in the construction of complex nitrogen-containing heterocycles and active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for process development and scale-up.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides that require specific chiral or sterically hindered amine components.
• Ligand and Catalyst Preparation: Serves as a precursor for nitrogen-donor ligands used in asymmetric catalysis and metal complex formation.
• Peptidomimetic Research: Employed in medicinal chemistry for creating constrained peptide analogs and protease inhibitors.
• Polymer Modification: Acts as a functional monomer or cross-linking agent for specialty polymers with tailored properties.
• Academic & R&D: A valuable reagent for methodological studies in organic chemistry, including novel cyclization and protection/deprotection strategies.

Basic Information

Product Name	tert-Butyl 3A,4,7,7A-Tetrahydro-1H-Isoindole-2(3H)-Carboxylate
CAS No.	1241675-29-5
Molecular Formula	C13H21NO2
Molecular Weight	223.31 g/mol
Synonyms	1,3,3a,4,7,7a-Hexahydro-2H-isoindole-2-carboxylic acid 1,1-dimethylethyl ester; tert-Butyl hexahydro-1H-isoindole-2(3H)-carboxylate; Boc-protected hexahydroisoindoline; 2-Boc-2,3,3a,4,7,7a-hexahydro-1H-isoindole; 3a,4,7,7a-Tetrahydro-1H-isoindole-2(3H)-carboxylic acid tert-butyl ester; N-Boc-3a,4,7,7a-tetrahydroisoindoline
EINECS	Contact for details

Quality Control

Our tert-Butyl 3A,4,7,7A-Tetrahydro-1H-Isoindole-2(3H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to prevent moisture absorption and potential degradation. Store away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.