Description

4-Acetamidocyclohexanol-D10 is a deuterated derivative of 4-acetamidocyclohexanol, where ten hydrogen atoms are replaced with deuterium, serving as a stable isotope-labeled internal standard. This compound is critically important for ensuring accuracy and reliability in quantitative mass spectrometry and metabolic studies, where it compensates for matrix effects and instrument variability. It is primarily needed by analytical laboratories, pharmaceutical researchers, and contract research organizations (CROs) engaged in drug metabolism and pharmacokinetics (DMPK) research, bioanalytical method development, and forensic analysis.

Application

• Internal Standard for LC-MS/MS: Essential for the precise quantification of 4-acetamidocyclohexanol and related metabolites in complex biological matrices like plasma, urine, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in absorption, distribution, metabolism, and excretion (ADME) studies to track the fate of pharmaceutical compounds.
• Bioanalytical Method Development and Validation: Provides a critical reference point for developing robust, sensitive, and reproducible analytical assays in compliance with regulatory guidelines (e.g., FDA, EMA).
• Forensic and Clinical Toxicology: Aids in the accurate detection and measurement of specific compounds or their biomarkers in forensic investigations and clinical diagnostic tests.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-precision analytical techniques where the deuterated analog is used to spike samples for absolute quantification.
• Metabolomics and Proteomics Research: Facilitates the accurate profiling of metabolites and proteins in systems biology studies.

Basic Information

Product Name	4-Acetamidocyclohexanol-D10
CAS No.	1241045-79-3
Molecular Formula	C8D10H5NO2
Molecular Weight	~157.23 g/mol (deuterated form)
Synonyms	4-Acetamidocyclohexanol-d10; N-(4-Hydroxycyclohexyl)acetamide-d10; 4-(Acetylamino)cyclohexanol-d10; Acetamide, N-(4-hydroxycyclohexyl)-, d10; Deuterated 4-Acetamidocyclohexanol; Cyclohexanol, 4-acetamido-, D10; Stable Isotope Labeled 4-Acetamidocyclohexanol; Internal Standard for 4-Acetamidocyclohexanol
EINECS	Contact for details

Quality Control

Our deuterated standards are produced and controlled under stringent quality management systems to ensure the highest levels of isotopic purity and chemical integrity, which are critical for reliable analytical results. Each batch of 4-Acetamidocyclohexanol-D10 is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic purity (atom % D), chemical purity (by HPLC), and identity confirmation (by NMR and MS). We support compliance with GMP/GLP principles for research and can provide materials suitable for regulated bioanalytical studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (Atom % D)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.