Description

2-tert-Butoxycarbonylamino-4,5,6,7-Tetrahydro-Benzo[B]Thiophene-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its bicyclic tetrahydrobenzothiophene core. This compound is a critical building block in the synthesis of complex molecules, offering a protected amine functionality and a carboxylic acid handle for further derivatization. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and drug candidates, particularly those targeting neurological and oncological pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug molecules and novel active pharmaceutical ingredients (APIs).
• Protease Inhibitor Research: Serves as a core scaffold in the development of protease inhibitors due to its structural similarity to privileged pharmacophores.
• Kinase Inhibitor Development: Used in medicinal chemistry programs aimed at creating selective kinase inhibitors for oncology and inflammatory diseases.
• Peptidomimetic Synthesis: The Boc-protected amino group and carboxylic acid make it a valuable fragment for constructing peptidomimetics and constrained peptide analogs.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for target identification and validation studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	2-tert-Butoxycarbonylamino-4,5,6,7-Tetrahydro-Benzo[B]Thiophene-3-Carboxylic Acid
CAS No.	1240361-06-1
Molecular Formula	C15H21NO4S
Molecular Weight	311.40 g/mol
Synonyms	2-((tert-Butoxycarbonyl)amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid; 2-(Boc-amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid; Boc-Amino-Tetrahydrobenzothiophene-3-Carboxylic Acid; 2-(tert-Butoxycarbonylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid; 1240361-06-1; 2-Boc-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 2-tert-Butoxycarbonylamino-4,5,6,7-Tetrahydro-Benzo[B]Thiophene-3-Carboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the stringent requirements for pharmaceutical R&D and process development. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is stable under these conditions for extended periods. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.