Description

2-(4-Acetylpiperazin-1-Yl)Pyridine-5-Boronic Acid is a high-value boronic acid derivative and a key building block in modern synthetic chemistry. This compound matters for its crucial role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers for developing novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic research.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid reagent for forming carbon-carbon bonds between aromatic rings, essential for creating complex biaryl structures.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides with improved efficacy.
• Material Science Research: Employed in the development of organic electronic materials, such as ligands for metal-organic frameworks (MOFs) and organic light-emitting diodes (OLEDs).
• Chemical Biology & Proteomics: Acts as a functional handle in the design of chemical probes and affinity tags for studying protein function and interactions.
• Library Synthesis for Drug Discovery: Enables the rapid generation of diverse compound libraries via parallel synthesis for high-throughput screening (HTS) campaigns.

Basic Information

Product Name	2-(4-Acetylpiperazin-1-Yl)Pyridine-5-Boronic Acid
CAS No.	1236360-37-4
Molecular Formula	C11H16BN3O3
Molecular Weight	249.08 g/mol
Synonyms	5-Pyridineboronic acid, 2-[4-(acetyl-1-piperazinyl)]-; 2-(4-Acetyl-1-piperazinyl)-5-pyridineboronic acid; 2-(4-Acetylpiperazin-1-yl)pyridine-5-boronic acid; 2-(N-Acetylpiperazin-1-yl)pyridine-5-boronic acid; 1-[5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]-4-acetylpiperazine (Pinacol ester precursor); 2-(4-Acetylpiperazin-1-yl)-5-boronopyridine; CAS 1236360-37-4
EINECS	Contact for details

Quality Control

Our 2-(4-Acetylpiperazin-1-Yl)Pyridine-5-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance for sensitive coupling reactions. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.