Description

1-Boc-3-(Mercaptomethyl)-Azetidine is a high-value, protected heterocyclic building block featuring both a Boc-protected amine and a reactive thiol group. This compound is critical for medicinal chemistry and pharmaceutical research, enabling the synthesis of complex molecules with enhanced stability and bioavailability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel azetidine-containing scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in protease inhibitor and kinase inhibitor research.
• Peptidomimetics: Used to introduce constrained azetidine rings and thioether linkages into peptide analogs to improve metabolic stability and binding affinity.
• Bioconjugation Chemistry: The free thiol group allows for site-specific conjugation to maleimides, halides, or other electrophiles in antibody-drug conjugate (ADC) linker development.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Serves as a precursor for activity-based probes that target cysteine residues in proteins.
• Agrochemical Research: Intermediate in the development of new crop protection agents with novel modes of action.

Basic Information

Product Name	1-Boc-3-(Mercaptomethyl)-Azetidine
CAS No.	1236007-18-3
Molecular Formula	C9H17NO2S
Molecular Weight	203.30 g/mol
Synonyms	tert-Butyl 3-(mercaptomethyl)azetidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-(mercaptomethyl)azetidine; 3-(Mercaptomethyl)azetidine-1-carboxylic acid tert-butyl ester; 1-Boc-3-mercaptomethylazetidine; Azetidine-1-carboxylic acid, 3-(mercaptomethyl)-, 1,1-dimethylethyl ester; BOC-Azetidine-CH2SH
EINECS	Contact for details

Quality Control

Our 1-Boc-3-(Mercaptomethyl)-Azetidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for water content, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation of the thiol group and prolong shelf life. Keep the container in a cool, dry, and well-ventilated area separate from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.