Description

1H-Indazole, 1-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in enabling efficient, selective cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the indazole core provides specific biological activity.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized to create labeled compounds and molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring high-fidelity boronic ester chemistry.

Basic Information

Product Name	1H-Indazole, 1-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1235469-00-7
Molecular Formula	C₁₄H₁₉BN₂O₂
Molecular Weight	258.13 g/mol
Synonyms	1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methyl-1H-indazole; 1-Methyl-1H-indazole-5-boronic acid pinacol ester; 1-Methyl-5-(pinacolboryl)-1H-indazole; 1-Methylindazole-5-boronic acid pinacol ester; 5-Borono-1-methyl-1H-indazole pinacol ester; 1-Methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole
EINECS	Contact for details

Quality Control

Our 1H-Indazole, 1-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for sensitive cross-coupling applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.