Description

4-Bromo-5-Nitro-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Pyrazole CAS NO 1235407-34-7 is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyrazole core protected by a tetrahydropyran (THP) group. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with potential biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting specific enzyme pathways.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides due to its reactive nitro and bromo functional groups.
• Material Science: Serves as a monomer or functionalizing agent in the creation of specialized polymers and advanced materials.
• Chemical Synthesis: Acts as a versatile scaffold for constructing complex heterocyclic compounds in academic and industrial R&D laboratories.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands for metal-catalyzed reactions.

Basic Information

Product Name	4-Bromo-5-Nitro-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Pyrazole
CAS No.	1235407-34-7
Molecular Formula	C8H10BrN3O3
Molecular Weight	276.09 g/mol
Synonyms	1-(Tetrahydro-2H-pyran-2-yl)-4-bromo-5-nitro-1H-pyrazole; 4-Bromo-5-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole; 1H-Pyrazole, 4-bromo-5-nitro-1-(tetrahydro-2H-pyran-2-yl)-; 4-Bromo-5-nitro-1-(oxan-2-yl)-1H-pyrazole; THP-protected 4-bromo-5-nitropyrazole; 4-Br-5-NO2-1-THP-pyrazole
EINECS	Contact for details

Quality Control

Our 4-Bromo-5-Nitro-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Pyrazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.