Description

5,6,7,8-Tetradeuterio-2-[(2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-Tetraenyl]-3-(Trideuteriomethyl)Naphthalene-1,4-Dione is a deuterated analog of menaquinone-4 (Vitamin K2), specifically designed for research and development applications requiring stable isotope labeling. This high-purity compound is critical for advanced analytical studies, including metabolic pathway tracing, pharmacokinetics, and mass spectrometry-based quantification. It serves as an essential tool for pharmaceutical researchers, analytical chemists, and life science professionals working on vitamin K biology, drug development, and nutritional studies.

Application

• Internal Standard for LC-MS/MS Analysis: Used as a stable isotope-labeled internal standard for the precise and accurate quantification of menaquinone-4 (MK-4) in complex biological matrices like plasma, tissues, and food products.
• Metabolic Pathway Tracing: Enables the study of Vitamin K2 absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research through deuterium labeling.
• Pharmaceutical R&D: Supports drug discovery and development programs focused on Vitamin K-dependent proteins, bone health, and cardiovascular research.
• Nutraceutical & Dietary Supplement Analysis: Facilitates the quality control and potency verification of Vitamin K2 (MK-4) in finished products and raw materials.
• Biochemical Research: Employed in mechanistic studies to investigate the role of Vitamin K2 in cellular processes, including carboxylation and signaling pathways.
• Reference Standard: Serves as a high-purity certified reference material (CRM) for method development, validation, and calibration in analytical laboratories.

Basic Information

Product Name	5,6,7,8-Tetradeuterio-2-[(2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-Tetraenyl]-3-(Trideuteriomethyl)Naphthalene-1,4-Dione
CAS No.	1233937-25-1
Molecular Formula	C31H37D7O2
Molecular Weight	469.73 g/mol (approx.)
Synonyms	Deuterated Vitamin K2 (MK-4); [D7]-Menaquinone-4; [D7]-MK-4; 5,6,7,8-Tetradeutero-2-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl]-3-(trideuteriomethyl)-1,4-naphthalenedione; Deuterated Menatetrenone; [D7]-2-Methyl-3-all-trans-tetraprenyl-1,4-naphthoquinone
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and high-resolution mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided, detailing parameters such as chemical purity, isotopic enrichment (D-content), and identification. We support research compliance and data integrity for global markets.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the product may be stored at 2-8°C. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.