Description

Dl-Tryptophan-D8 CAS NO 1233395-85-1 is a deuterium-labeled isotopologue of the essential amino acid tryptophan, where eight hydrogen atoms are replaced with deuterium. This high-purity, stable-labeled compound is critical for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is primarily utilized by research scientists and quality control laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors for advanced metabolic studies, pharmacokinetic research, and precise bioanalytical method development.

Application

• Mass Spectrometry Internal Standard: Serves as a critical reference compound for the accurate quantification of endogenous tryptophan and related metabolites in complex biological matrices via LC-MS/MS and GC-MS.
• Pharmaceutical R&D: Enables precise drug metabolism and pharmacokinetics (DMPK) studies, including absorption, distribution, metabolism, and excretion (ADME) profiling of new chemical entities.
• Clinical Research & Diagnostics: Used in developing high-sensitivity assays for monitoring tryptophan pathway disorders, neurological research, and biomarker discovery.
• Metabolomics & Proteomics: Facilitates stable isotope labeling and tracing experiments to study metabolic fluxes, protein turnover, and cellular pathways.
• Nutritional Science Research: Applied in studies investigating amino acid metabolism, protein synthesis, and the role of tryptophan in health and disease.
• Quality Control & Method Validation: Essential for validating analytical methods in GLP/GMP-compliant laboratories to ensure data integrity and regulatory compliance.

Basic Information

Product Name	Dl-Tryptophan-D8
CAS No.	1233395-85-1
Molecular Formula	C11H4D8N2O2
Molecular Weight	~212.27 g/mol
Synonyms	(±)-Tryptophan-d8; DL-Tryptophan-α,β,β,2,4,5,6,7-d8; Tryptophan-d8 (racemic); 2-Amino-3-(1H-indol-3-yl)propanoic-α,β,β,2,4,5,6,7-d8 acid; 3-(1H-Indol-3-yl)-dl-alanine-d8; Racemic Tryptophan-d8; Tryptophan (ring-d5, alanyl-α,β,β-d3); Deuterated DL-Tryptophan
EINECS	Contact for details

Quality Control

Our Dl-Tryptophan-D8 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % D), chemical purity (by HPLC), and identification. We adhere to industry best practices, and specifications can be tailored to meet the rigorous standards of GLP, GMP, and ISO 17025 compliant laboratories. Certificates of Analysis are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant and inert atmosphere to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.