Description

8-Bromo-1-Chloroisoquinoline is a high-purity halogenated isoquinoline derivative, a versatile and critical building block in advanced organic synthesis. Its unique bifunctional halogenated structure makes it an indispensable intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogenated motifs for further functionalization.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting kinase inhibition and other therapeutic pathways.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and pesticides, leveraging its halogenated scaffold.
• Material Science Research: Serves as a building block for creating organic electronic materials, ligands for metal-organic frameworks (MOFs), and photoactive compounds.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions such as Suzuki, Negishi, and Buchwald-Hartwig amination, enabling carbon-carbon and carbon-heteroatom bond formation.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and enzyme functions.
• Ligand Synthesis: Acts as a starting material for the preparation of complex chelating ligands used in catalysis and coordination chemistry.

Basic Information

Product Name	8-Bromo-1-Chloroisoquinoline
CAS No.	1233025-78-9
Molecular Formula	C9H5BrClN
Molecular Weight	242.50 g/mol
Synonyms	1-Chloro-8-bromoisoquinoline; 8-Bromo-1-chloro-isoquinoline; Isoquinoline, 8-bromo-1-chloro-; 8-Brom-1-chlorisochinolin (German); 8-ブロモ-1-クロロイソキノリン (Japanese); 8-溴-1-氯异喹啉 (Chinese); BCIQ (common abbreviation)
EINECS	Contact for details

Quality Control

Every batch of 8-Bromo-1-Chloroisoquinoline is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC Area %)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.