Description

5-Chloroisoquinoline-1-Carbonitrile is a versatile and high-value heterocyclic building block used in advanced organic synthesis. This compound matters for its role as a key precursor in the development of novel pharmaceuticals and agrochemicals, enabling the construction of complex molecular architectures. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical scaffold in the synthesis of potential drug candidates, particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its chlorinated isoquinoline core.
• Material Science Precursor: Acts as a building block for organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Chemical Biology Probe: Utilized in the design and synthesis of molecular probes for studying biological pathways and enzyme functions.
• Catalyst Ligand Development: The nitrile and chloro groups provide handles for modification into novel ligands for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring specialized isoquinoline derivatives.

Basic Information

Product Name	5-Chloroisoquinoline-1-Carbonitrile
CAS No.	1231761-25-3
Molecular Formula	C10H5ClN2
Molecular Weight	188.61 g/mol
Synonyms	1-Cyano-5-chloroisoquinoline; 5-Chloro-1-cyanoisoquinoline; 5-Chloroisoquinoline-1-carbonitrile; Isoquinoline-1-carbonitrile, 5-chloro-; 5-Chloro-isoquinoline-1-carbonitrile
EINECS	Contact for details

Quality Control

Our 5-Chloroisoquinoline-1-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We adhere to cGMP principles for advanced intermediates to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for prolonged stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.