Description

2,4-Dihydro-5-Methyl-2-(Phenyl-2,3,4,5,6-D5)-3H-Pyrazol-3-One CAS NO 1228765-67-0 is a deuterated derivative of a pyrazolone compound, where the phenyl ring is fully substituted with five deuterium atoms. This high-purity labeled compound is critical for advanced analytical and research applications where isotopic tracing is required. It is primarily utilized by pharmaceutical research organizations, analytical laboratories, and chemical manufacturers developing deuterated active pharmaceutical ingredients (APIs) and internal standards.

Application

• Pharmaceutical Research & Development: Serves as a key deuterated intermediate or building block in the synthesis of novel drug candidates, particularly for pharmacokinetic and metabolic studies.
• Analytical Chemistry: Used as a high-purity internal standard for quantitative analysis via Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS), improving assay accuracy and reliability.
• Metabolite Tracing: Enables precise tracking of metabolic pathways and drug degradation products in biological systems due to its stable isotopic label.
• Material Science Research: Investigated for its potential in the development of specialized organic materials and ligands where isotopic purity can influence physical properties.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of deuterated pharmaceutical compounds.

Basic Information

Product Name	2,4-Dihydro-5-Methyl-2-(Phenyl-2,3,4,5,6-D5)-3H-Pyrazol-3-One
CAS No.	1228765-67-0
Molecular Formula	C10H5D5N2O
Molecular Weight	179.23 g/mol
Synonyms	5-Methyl-2-(pentadeuteriophenyl)-2,4-dihydro-3H-pyrazol-3-one; 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-(phenyl-2,3,4,5,6-d5)-; Deuterated Antipyrine derivative; 2-(Phenyl-d5)-5-methyl-2,4-dihydro-3H-pyrazol-3-one; 5-Methyl-2-(2,3,4,5,6-pentadeuteriophenyl)-2,4-dihydro-3H-pyrazol-3-one; d5-Pyrazolone derivative; Labeled Pyrazolone
EINECS	Contact for details

Quality Control

Every batch of 2,4-Dihydro-5-Methyl-2-(Phenyl-2,3,4,5,6-D5)-3H-Pyrazol-3-One is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and isotopic enrichment. Our quality system is designed to meet the stringent requirements of research and development. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), isotopic purity (by NMR/MS), and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.