Description

5-Fluoro-3,4-Diiodo-1H-Pyrrolo[2,3-B]Pyridine is a high-value, multi-halogenated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular architecture, which serves as a versatile scaffold for constructing complex pharmacophores and functional materials. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel kinase inhibitors, anticancer agents, and other biologically active small molecules.
• Agrochemical Research: Used to develop new active ingredients for crop protection products, leveraging its halogenated pyrrolopyridine core.
• Material Science: Serves as a building block for organic electronic materials, such as ligands for OLEDs or charge-transport materials.
• Chemical Biology: Employed as a molecular probe or a tag in medicinal chemistry programs due to the reactivity of the iodine atoms.
• Cross-Coupling Reactions: The diiodo-substitution pattern makes it an excellent substrate for sequential palladium-catalyzed cross-coupling reactions (e.g., Sonogashira, Suzuki, Negishi).
• Academic & Contract Research: Utilized in universities and CROs for methodological development and exploring new chemical spaces.

Basic Information

Product Name	5-Fluoro-3,4-Diiodo-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1228666-23-6
Molecular Formula	C7H3F I2N2
Molecular Weight	387.92 g/mol
Synonyms	5-Fluoro-3,4-diiodo-1H-pyrrolo[2,3-b]pyridine; 3,4-Diiodo-5-fluoro-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 5-fluoro-3,4-diiodo-; 5-Fluoro-3,4-diiodo-7-azaindole; 3,4-Diiodo-5-fluoro-7-azaindole; 5-F-3,4-I2-7AI
EINECS	Contact for details

Quality Control

Our 5-Fluoro-3,4-Diiodo-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), identity confirmation (NMR, IR), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.