Description

5-(Trifluoromethyl)-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine CAS NO 1228666-22-5 is a high-value, organosilicon-protected heterocyclic building block featuring a trifluoromethyl group. This compound is critical for medicinal chemistry and agrochemical research, where its unique structure enables the fine-tuning of pharmacokinetic properties and biological activity. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and advanced agrochemical industries for constructing novel active molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the discovery and development of new active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used to create novel herbicides, fungicides, and insecticides where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Material Science Precursor: Serves as a specialized monomer or functionalizing agent for advanced polymers and organic electronic materials.
• Cross-Coupling Reactions: The triisopropylsilyl (TIPS) protecting group allows for selective functionalization of the pyrrolopyridine core in complex multi-step syntheses.
• Fluorine Chemistry Building Block: Essential for introducing the CF3 moiety into complex molecules to modulate their electronic properties and bioavailability.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and custom synthesis projects for global clients.

Basic Information

Product Name	5-(Trifluoromethyl)-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1228666-22-5
Molecular Formula	C18H27F3N2Si
Molecular Weight	356.51 g/mol
Synonyms	1-(Triisopropylsilyl)-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 5-Trifluoromethyl-1-triisopropylsilyl-1H-pyrrolo[2,3-b]pyridine; TIPS-5-CF3-Pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 5-(trifluoromethyl)-1-[(triisopropylsilyl)]-; 1228666-22-5
EINECS	Contact for details

Quality Control

Our production of 5-(Trifluoromethyl)-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine adheres to stringent in-process controls to ensure batch-to-batch consistency and high chemical purity. We provide comprehensive analytical data including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every batch and supplied with each order to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.