Description

6-Quinazolinol, 4-[(3-Chloro-4-Fluorophenyl)Amino]-7-(Methoxy-D3)- is a deuterated quinazoline derivative, a key intermediate in the development of targeted therapeutic agents. This compound matters for its role in creating deuterium-labeled drug candidates, which can offer improved metabolic stability and pharmacokinetic profiles. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of advanced kinase inhibitors and other specialized active pharmaceutical ingredients (APIs).

Application

• Critical intermediate in the synthesis of deuterated pharmaceutical compounds for clinical research.
• Building block for the development of novel kinase inhibitors targeting specific oncogenic pathways.
• Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Precursor material in the production of high-value, labeled compounds for metabolism and pharmacokinetics (DMPK) studies.
• Key starting material (KSM) or advanced intermediate in custom synthesis and contract manufacturing.
• Reference standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	6-Quinazolinol, 4-[(3-Chloro-4-Fluorophenyl)Amino]-7-(Methoxy-D3)-
CAS No.	1228665-04-0
Molecular Formula	C15H10D3ClFN3O2
Molecular Weight	321.76 g/mol
Synonyms	4-[(3-Chloro-4-fluorophenyl)amino]-7-(methoxy-d3)quinazolin-6-ol; 7-(Methoxy-d3)-4-((3-chloro-4-fluorophenyl)amino)quinazolin-6-ol; Deuterated Afatinib Intermediate; D3-Methoxy Gefitinib/Afatinib Analog; 6-Hydroxy-7-(methoxy-d3)-4-((3-chloro-4-fluorophenyl)amino)quinazoline; BIBW 2992 (D3-methoxy) Intermediate; 1228665-04-0; 4-((3-Chloro-4-fluorophenyl)amino)-7-(trideuteromethoxy)quinazolin-6-ol
EINECS	Contact for details

Quality Control

Our 6-Quinazolinol, 4-[(3-Chloro-4-Fluorophenyl)Amino]-7-(Methoxy-D3)- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and isotopic enrichment meet exacting standards. Certificates of Analysis (COA) with full traceability are provided and can be tailored to meet specific GMP or ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants or an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Incorporation (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.