Description

Ethyl 3-Bromo-5-(Trifluoromethoxy)-1H-Indole-2-Carboxylate is a high-value, multi-functional indole derivative that serves as a critical synthetic building block in advanced organic chemistry. Its molecular structure, featuring bromine and trifluoromethoxy substituents, makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the indole core and halogenated motifs can contribute to biological activity.
• Material Science: Serves as a building block for creating advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Biology: Employed as a probe or labeling reagent in biochemical research due to its reactive bromine handle for further functionalization.
• Academic & Contract Research: Essential for method development and discovery chemistry in university and CRO (Contract Research Organization) laboratories.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, high-value fine chemicals for various industrial applications.

Basic Information

Product Name	Ethyl 3-Bromo-5-(Trifluoromethoxy)-1H-Indole-2-Carboxylate
CAS No.	1227955-21-6
Molecular Formula	C₁₂H₉BrF₃NO₃
Molecular Weight	352.11 g/mol
Synonyms	3-Bromo-5-(trifluoromethoxy)-1H-indole-2-carboxylic acid ethyl ester; Ethyl 3-bromo-5-(trifluoromethoxy)indole-2-carboxylate; 1H-Indole-2-carboxylic acid, 3-bromo-5-(trifluoromethoxy)-, ethyl ester; 1227955-21-6; 3-Bromo-5-trifluoromethoxy-indole-2-carboxylic acid ethyl ester.
EINECS	Contact for details

Quality Control

Our Ethyl 3-Bromo-5-(Trifluoromethoxy)-1H-Indole-2-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality management system is designed to meet the rigorous standards required by pharmaceutical and advanced research customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.