Description

Ethyl 3-(1H-Pyrrol-1-Yl)-5-(Trifluoromethyl)-1-Benzothiophene-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its benzothiophene core functionalized with pyrrole and trifluoromethyl groups. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with enhanced metabolic stability and bioavailability. It is primarily needed by R&D teams and process chemists in the pharmaceutical and agrochemical industries for developing new active ingredients targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug molecules, particularly in oncology, CNS disorders, and anti-inflammatory therapies.
• Agrochemical Research: Serves as a precursor in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the biological activity of the benzothiophene scaffold.
• Material Science Precursor: Used in the development of organic semiconductors and advanced functional materials due to its conjugated π-system.
• Chemical Biology Probe: Employed in academic and industrial research to study enzyme inhibition and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the scale-up and production of client-specific target molecules under cGMP conditions.

Basic Information

Product Name	Ethyl 3-(1H-Pyrrol-1-Yl)-5-(Trifluoromethyl)-1-Benzothiophene-2-Carboxylate
CAS No.	1227954-97-3
Molecular Formula	C₁₆H₁₂F₃NO₂S
Molecular Weight	339.33 g/mol
Synonyms	Ethyl 3-(1H-pyrrol-1-yl)-5-(trifluoromethyl)benzo[b]thiophene-2-carboxylate; 5-(Trifluoromethyl)-3-(1-pyrrolyl)-1-benzothiophene-2-carboxylic Acid Ethyl Ester; 1-Benzothiophene-2-carboxylic acid, 3-(1H-pyrrol-1-yl)-5-(trifluoromethyl)-, ethyl ester; 1227954-97-3; Ethyl 3-pyrrol-1-yl-5-trifluoromethyl-1-benzothiophene-2-carboxylate
EINECS	Contact for details

Quality Control

Our Ethyl 3-(1H-Pyrrol-1-Yl)-5-(Trifluoromethyl)-1-Benzothiophene-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with stringent industry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.