Description

Phosphine Oxide, [(2R)-2,3-Dimethyl-3-[(Triethylsilyl)Oxy]Butyl]Diphenyl- is a chiral, organosilicon-protected phosphine oxide derivative that serves as a versatile synthetic intermediate and ligand precursor in advanced organic synthesis. Its molecular architecture, featuring both a stereogenic center and a silyl ether protecting group, makes it particularly valuable for constructing complex, optically active molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity chiral building blocks.

Application

• Chiral Ligand Synthesis: A key precursor for the preparation of enantiomerically pure phosphine ligands used in asymmetric catalysis.
• Pharmaceutical Intermediates: Employed in the synthesis of active pharmaceutical ingredients (APIs) where stereochemical control is critical.
• Agrochemical Development: Used in the research and production of chiral herbicides, fungicides, and plant growth regulators.
• Organometallic Chemistry: Serves as a starting material for metal complexes in homogeneous catalysis.
• Material Science Research: Investigated for the development of novel chiral polymers and functional materials.
• Process Chemistry: Utilized in scale-up and optimization of synthetic routes for commercial manufacturing.

Basic Information

Product Name	Phosphine Oxide, [(2R)-2,3-Dimethyl-3-[(Triethylsilyl)Oxy]Butyl]Diphenyl-
CAS No.	1227926-70-6
Molecular Formula	C24H37O2PSi
Molecular Weight	416.61 g/mol
Synonyms	((2R)-2,3-Dimethyl-3-((triethylsilyl)oxy)butyl)diphenylphosphine oxide; (R)-2,3-Dimethyl-3-(triethylsilyloxy)butyl-diphenylphosphine oxide; Diphenyl-[(2R)-2,3-dimethyl-3-(triethylsilyloxy)butyl]phosphine oxide; (R)-TES-Protected Phosphine Oxide Alcohol; Chiral Silyl Ether Phosphine Oxide; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized using advanced analytical techniques including Chiral HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), enantiomeric excess, and impurity profile is provided with every shipment. We support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.