Description

4-Bromo-6-Fluoroisoquinolin-1(2H)-One is a high-value, multi-functional heterocyclic building block essential for modern synthetic chemistry. Its core value lies in its unique halogenated isoquinolinone structure, which provides versatile reactivity for constructing complex molecular architectures. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in kinase inhibitor and anticancer research programs.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and pesticides, leveraging its halogenated scaffold.
• Material Science Precursor: Serves as a building block for advanced organic electronic materials and functional polymers.
• Chemical Biology Probe: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and target identification.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions.
• Library Synthesis: Employed in high-throughput and combinatorial chemistry for generating diverse compound libraries for screening.

Basic Information

Product Name	4-Bromo-6-Fluoroisoquinolin-1(2H)-One
CAS No.	1227607-99-9
Molecular Formula	C9H5BrFNO
Molecular Weight	242.05 g/mol
Synonyms	4-Bromo-6-fluoroisoquinolin-1(2H)-one; 4-Bromo-6-fluoro-1,2-dihydroisoquinolin-1-one; 4-Bromo-6-fluoro-2H-isoquinolin-1-one; 1(2H)-Isoquinolinone, 4-bromo-6-fluoro-; 4-Bromo-6-fluoro-1H-isoquinolin-1-one; 6-Fluoro-4-bromoisoquinolin-1(2H)-one
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-6-Fluoroisoquinolin-1(2H)-One is produced under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for research and development. Certificates of Analysis (COA) with full characterization data are provided to guarantee compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.