Description

1-(Phenylsulphonyl)-3-Nitro-7-Azaindole CAS NO 1227270-86-1 is a high-purity, advanced pharmaceutical intermediate belonging to the azaindole class of heterocyclic compounds. This compound serves as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel drug candidates, particularly kinase inhibitors.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Tool Compound: Employed in biochemical assays to study enzyme function and screen for potential therapeutic agents.
• Organic Synthesis Building Block: Utilized in multi-step organic syntheses to construct complex molecules for academic and industrial research.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the production of active pharmaceutical ingredients (APIs) under cGMP conditions.

Basic Information

Product Name	1-(Phenylsulphonyl)-3-Nitro-7-Azaindole
CAS No.	1227270-86-1
Molecular Formula	C13H9N3O4S
Molecular Weight	303.29 g/mol
Synonyms	1-(Phenylsulfonyl)-3-nitro-1H-pyrrolo[2,3-b]pyridine; 3-Nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 3-nitro-1-(phenylsulfonyl)-; 1-(Benzenesulfonyl)-3-nitro-7-azaindole; 3-Nitro-1-(phenylsulfonyl)-7-azaindole; 7-Azaindole, 1-(phenylsulfonyl)-3-nitro-; 1227270-86-1
EINECS	Contact for details

Quality Control

Our 1-(Phenylsulphonyl)-3-Nitro-7-Azaindole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our quality commitment supports applications requiring high standards, from research to cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.