Description

1-(Phenylsulphonyl)-4-Chloro-7-Azaindole-2-Carbaldehyde is a high-purity, synthetically valuable heterocyclic building block. This compound is a key advanced intermediate in modern pharmaceutical research, particularly for the development of kinase inhibitors and other small molecule therapeutics. It is primarily utilized by research scientists and process chemists in the pharmaceutical, biotechnology, and fine chemical industries for lead optimization and active pharmaceutical ingredient (API) synthesis.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel kinase inhibitors targeting various disease pathways.
• Medicinal Chemistry Research: Used in lead compound generation and structure-activity relationship (SAR) studies due to its versatile functional groups.
• Organic Synthesis: Serves as a precursor for constructing complex nitrogen-containing heterocycles via further derivatization of the aldehyde and chloro substituents.
• Biochemical Tool Development: Potential use in creating molecular probes for studying enzyme function and cellular signaling processes.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of novel chemical entities.

Basic Information

Item	Detail
Product Name	1-(Phenylsulphonyl)-4-Chloro-7-Azaindole-2-Carbaldehyde
CAS No.	1227270-81-6
Molecular Formula	C15H9ClN2O3S
Molecular Weight	332.76 g/mol
Synonyms	4-Chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-2-carbaldehyde; 4-Chloro-1-(phenylsulfonyl)-7-azaindole-2-carboxaldehyde; 1H-Pyrrolo[2,3-b]pyridine-2-carboxaldehyde, 4-chloro-1-(phenylsulfonyl)-; 4-Chloro-1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine-2-carbaldehyde; 1-(Phenylsulfonyl)-4-chloro-7-azaindole-2-carbaldehyde; 1-Benzenesulfonyl-4-chloro-7-azaindole-2-carbaldehyde
EINECS	Contact for details

Quality Control

Our 1-(Phenylsulphonyl)-4-Chloro-7-Azaindole-2-Carbaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized and should be handled and stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.