Description

3-Iodo-5-Chloro-(1H)Indazole-6-Carboxylic Methyl Ester CAS NO 1227270-79-2 is a high-purity, functionalized indazole derivative designed for advanced chemical synthesis. This compound serves as a critical pharmaceutical intermediate and building block in medicinal chemistry, enabling the development of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the discovery of new drug candidates, particularly in oncology and targeted therapies.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex small-molecule drugs and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile building block for constructing indazole-based compound libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Kinase Inhibitor Development: The halogenated indazole core is a privileged scaffold in the design of potent and selective kinase inhibitors for cancer treatment.
• Agrochemical Research: Potential intermediate in the development of new herbicides and fungicides.
• Material Science: Can be employed in the synthesis of specialty polymers and advanced organic electronic materials.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.

Basic Information

Product Name	3-Iodo-5-Chloro-(1H)Indazole-6-Carboxylic Methyl Ester
CAS No.	1227270-79-2
Molecular Formula	C9H6ClIN2O2
Molecular Weight	336.51 g/mol
Synonyms	Methyl 3-Iodo-5-Chloro-1H-indazole-6-carboxylate; 6-Carbomethoxy-5-chloro-3-iodo-1H-indazole; 3-Iodo-5-chloro-1H-indazole-6-carboxylic acid methyl ester; 5-Chloro-3-iodo-1H-indazole-6-carboxylic acid methyl ester; 1H-Indazole-6-carboxylic acid, 5-chloro-3-iodo-, methyl ester; 1227270-79-2
EINECS	Contact for details

Quality Control

Our 3-Iodo-5-Chloro-(1H)Indazole-6-Carboxylic Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all specifications are provided with every shipment. We support cGMP compliance for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. The compound is light-sensitive; containers should be amber glass or opaque.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.