Description

1-(Phenylsulphonyl)-5-Bromo-4-Methyl-7-Azaindole is a high-purity, advanced pharmaceutical intermediate characterized by its unique azaindole core functionalized with bromo and phenylsulfonyl groups. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for the synthesis of novel, biologically active molecules. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of kinase inhibitors and other targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in oncology and inflammatory disease pathways.
• Kinase Inhibitor Synthesis: Serves as a privileged scaffold for constructing potent and selective kinase inhibitors due to the azaindole pharmacophore.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to explore new chemical space.
• Biochemical Probe Development: Employed in the creation of tool compounds for investigating specific biological targets and signaling pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production of active pharmaceutical ingredients (APIs).
• Academic Research: Used in university and institutional labs for fundamental research in organic synthesis and chemical biology.

Basic Information

Product Name	1-(Phenylsulphonyl)-5-Bromo-4-Methyl-7-Azaindole
CAS No.	1227270-76-9
Molecular Formula	C16H13BrN2O2S
Molecular Weight	377.26 g/mol
Synonyms	5-Bromo-4-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-4-methyl-1-(phenylsulfonyl)-7-azaindole; 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-4-methyl-1-(phenylsulfonyl)-; 5-Bromo-4-methyl-1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1-(Phenylsulfonyl)-5-bromo-4-methyl-7-azaindole; 5-Bromo-4-methyl-1-tosyl-7-azaindole (common misnomer); 1-(Phenylsulfonyl)-5-bromo-4-methyl-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 1-(Phenylsulphonyl)-5-Bromo-4-Methyl-7-Azaindole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing HPLC purity, NMR, and mass spectrometry data are provided with every shipment. We support compliance with relevant guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.