Description

1-(Phenylsulphonyl)-6-Methyl-5-Nitro-7-Azaindole is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, particularly in the creation of novel therapeutic agents targeting specific biological pathways. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel small-molecule drug candidates, particularly in oncology and antiviral research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop compounds with improved efficacy and pharmacokinetic profiles.
• API Synthesis: Serves as a precursor in the production route for complex Active Pharmaceutical Ingredients (APIs), especially those containing the 7-azaindole heterocyclic core.
• Biochemical Tool Compound: Can be utilized in the development of chemical probes for investigating enzyme function and cellular signaling pathways in academic and industrial research settings.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials and commercial APIs.

Basic Information

Product Name	1-(Phenylsulphonyl)-6-Methyl-5-Nitro-7-Azaindole
CAS No.	1227270-74-7
Molecular Formula	C16H13N3O4S
Molecular Weight	343.36 g/mol
Synonyms	1-(Phenylsulfonyl)-6-methyl-5-nitro-1H-pyrrolo[2,3-b]pyridine; 6-Methyl-5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 5-Nitro-6-methyl-1-(phenylsulfonyl)-7-azaindole; 1H-Pyrrolo[2,3-b]pyridine, 6-methyl-5-nitro-1-(phenylsulfonyl)-; 1-(Benzenesulfonyl)-6-methyl-5-nitro-7-azaindole; 5-Nitro-6-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 1-(Phenylsulphonyl)-6-Methyl-5-Nitro-7-Azaindole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality standards are designed to meet the stringent requirements of pharmaceutical R&D and cGMP manufacturing for clinical supplies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound should be kept under an inert atmosphere for long-term storage to ensure stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.