Description

1-(Phenylsulphonyl)-4-Cyano-2-Iodo-7-Azaindole is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound matters because it integrates a reactive iodo substituent, a cyano group, and a sulfonyl-protected nitrogen, offering versatile handles for cross-coupling, nucleophilic substitution, and further functionalization. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, particularly in medicinal chemistry programs targeting kinase inhibition.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, especially for kinase-targeted therapies.
• Medicinal Chemistry Probe: Used in structure-activity relationship (SAR) studies to explore and optimize biological activity.
• Agrochemical Synthesis: Serves as a building block for creating new active ingredients with potential herbicidal or insecticidal properties.
• Cross-Coupling Reactions: The iodine atom is an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings.
• Chemical Biology Tool: Can be utilized for labeling or modifying biomolecules due to its reactive functional groups.
• Material Science Research: Potential precursor for organic electronic materials or metal-organic frameworks (MOFs).

Basic Information

Product Name	1-(Phenylsulphonyl)-4-Cyano-2-Iodo-7-Azaindole
CAS No.	1227270-55-4
Molecular Formula	C14H8IN3O2S
Molecular Weight	409.20 g/mol
Synonyms	1-(Phenylsulfonyl)-4-cyano-2-iodo-1H-pyrrolo[2,3-b]pyridine; 2-Iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile; 4-Cyano-2-iodo-1-(phenylsulfonyl)-7-azaindole; 1H-Pyrrolo[2,3-b]pyridine-4-carbonitrile, 2-iodo-1-(phenylsulfonyl)-; 7-Azaindole, 1-(phenylsulfonyl)-4-cyano-2-iodo-; 1227270-55-4
EINECS	Contact for details

Quality Control

Our 1-(Phenylsulphonyl)-4-Cyano-2-Iodo-7-Azaindole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically ≥95% (HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards for research chemicals, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.