Description

3-Iodo-5-Methoxy-(1H)Indazole-6-Carboxylic Acid Methyl Ester is a high-value, multi-functional heterocyclic building block designed for advanced organic synthesis. This compound is critical for medicinal chemistry research and development, serving as a versatile intermediate in the creation of novel pharmaceutical candidates. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted small molecule drugs, particularly those exploring indazole-based scaffolds for oncology, CNS, and anti-inflammatory applications.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns for structure-activity relationship (SAR) studies due to its modifiable iodine and ester functional groups.
• Agrochemical Development: Serves as a building block for creating novel active ingredients for crop protection products.
• Chemical Biology Probes: Employed in the development of molecular probes and tools for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and non-GMP/GLP batches.
• Academic Research: Used in university and institutional labs for fundamental research in heterocyclic chemistry and new synthetic methodology development.

Basic Information

Product Name	3-Iodo-5-Methoxy-(1H)Indazole-6-Carboxylic Acid Methyl Ester
CAS No.	1227270-54-3
Molecular Formula	C10H9IN2O3
Molecular Weight	332.10 g/mol
Synonyms	Methyl 3-iodo-5-methoxy-1H-indazole-6-carboxylate; 6-Carbomethoxy-3-iodo-5-methoxyindazole; 3-Iodo-5-methoxy-1H-indazole-6-carboxylic acid methyl ester; 1H-Indazole-6-carboxylic acid, 3-iodo-5-methoxy-, methyl ester; Methyl 3-iodo-5-methoxyindazole-6-carboxylate
EINECS	Contact for details

Quality Control

Every batch of 3-Iodo-5-Methoxy-(1H)Indazole-6-Carboxylic Acid Methyl Ester is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A detailed Certificate of Analysis (COA) including HPLC purity, NMR, and mass spectrometry confirmation is supplied with each shipment to guarantee identity, purity, and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.