Description

1-(Phenylsulfonyl)-4,6-Dichloro-2-Iodo-7-Azaindole is a high-purity, multi-halogenated 7-azaindole derivative, a crucial advanced intermediate in modern pharmaceutical research and development. Its complex heterocyclic structure, featuring distinct sulfonyl, chloro, and iodo substituents, makes it an invaluable scaffold for constructing novel bioactive molecules. This compound is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of targeted therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of kinase inhibitors and other small-molecule drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization campaigns due to its versatile functional groups for further derivatization.
• Chemical Biology Probe Development: Employed in the creation of chemical probes to study specific enzyme functions and biological mechanisms.
• Process Chemistry & Scale-up: Acts as a critical intermediate in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs).
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for client projects.
• Academic Research: Utilized in university and institutional labs for pioneering research in heterocyclic chemistry and drug discovery methodologies.

Basic Information

Item	Detail
Product Name	1-(Phenylsulfonyl)-4,6-Dichloro-2-Iodo-7-Azaindole
CAS No.	1227270-53-2
Molecular Formula	C13H7Cl2IN2O2S
Molecular Weight	467.08 g/mol
Synonyms	4,6-Dichloro-2-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 4,6-dichloro-2-iodo-1-(phenylsulfonyl)-; 7-Azaindole, 1-(phenylsulfonyl)-4,6-dichloro-2-iodo-; 4,6-Dichloro-2-iodo-1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 1-(Phenylsulfonyl)-4,6-Dichloro-2-Iodo-7-Azaindole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with the standards required for GMP intermediates and non-GMP research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.